PS-FERTILITY, INC.

PS-Detect: A Diagnostic Test for Male Fertility/Infertility

PS-FERTILITY, INC. is a company in eunice kennedy shriver national institute of child health and human development based in CHARLOTTESVILLE, VA, founded in 2022.

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Abstract: PS-DETECT: A DIAGNOSTIC TEST FOR MALE FERTILITY/INFERTILITY
The establishment of PS-Fertility, Inc was motivated by: 1) our recent findings from the laboratory that
phosphatidylserine (PS) on the surface of viable sperm is necessary for sperm:egg fusion; 2) that sperm can
fuse with myoblast cells in a PS-dependent manner; and 3) the inability of conventional semen analysis assays
to provide meaningful information about sperm function. Our overall goal of this SBIR is to refine our simple rapid
PS-Detect assay and further develop our business model. This assay will serve to quantify the potential
fertilization-competent sperm in an ejaculate.
Clinicians view semen analysis as a perfunctory assay, rather than an insightful test to acquire information
toward improved assisted reproductive technique strategies. Our market research, performed as part of the NSF
I-Corps program, revealed that, overwhelmingly, clinicians would welcome a diagnostic tool that could provide
new information about male infertility, specifically sperm health/function.
The premise for this application stems our preliminary studies, where we find an unexpected exposure of the
lipid phosphatidylserine (PS), which is normally associated with apoptotic cells, on the surface of viable and
motile sperm. Further, PS recognition receptors are expressed on the oocytes, and blocking/loss of some of
these

PS-FERTILITY, INC. is positioned in eunice kennedy shriver national institute of child health and human development, a segment that rewards a clear, focused offering.

The business is associated with CHARLOTTESVILLE, VA.

The company is listed at the SBIR/STTR stage of development.

Its team size is recorded as 1-10 employees.

Total disclosed funding stands at about $357K.

Website: psfertility.com