NEURONEXUS TECHNOLOGIES

Advanced culture and recording system for long-term electrophysiological profiling in human brain organoids

Operating in national institute of mental health based in Ann Arbor, MI, NEURONEXUS TECHNOLOGIES was founded in 2004.

Profile

Summary/Abstract
Brain organoids, derived from human pluripotent stem cells, represent a groundbreaking model system for
basic and applied neuroscience and drug development. A significant unmet need exists for better tools for
relating electrophysiological activity in neurons and neural circuits to molecular and cellular events over time.
This Phase I project will develop an integrated system for large-scale, chronic extracellular neural recording
and stimulation in brain organoids, focusing on innovative organoid assay chambers and 3D neural probes.
These devices will enable breakthrough studies to correlate molecular and cellular features with functional
neuronal and circuit properties across temporal scales from milliseconds to weeks. This project will be of
broad utility across basic neuroscience and translational research.
We aim to 1) Develop a biological assay chamber supporting chronic electrophysiology while maintaining
organoid health; 2) Develop high-fidelity, 3D neural probes for chronic, extracellular recording and stimulation;
and 3) Develop an integrated system for turn-key longitudinal electrophysiological assays in brain organoids
in cell biology labs.
The proposed electrophysiology system will provide, for the first time, a non-destructive, label-free, and high-
resolution longitudinal functional assay for diverse types of brain organoids. The system is design

As a business in national institute of mental health, NEURONEXUS TECHNOLOGIES is listed here with the public details available about it.

The company is recorded as being based in Ann Arbor, MI.

Its current recorded stage is SBIR/STTR.

Recorded headcount: c_00011_00050 employees.

It has disclosed roughly $45K in funding.

Website: neuronexus.com