APPLIED BIOPHYSICS, INC.

Development of an impedance-based cell assurance monitor to aid in identifying and characterizing cells in tissue culture

APPLIED BIOPHYSICS, INC. is active in the national institute of general medical sciences space based in TROY, NY, founded in 1991.

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There is concern regarding the quality of animal cells grown in tissue culture for scientific studies. It is
reported that many laboratories use misidentified cells or cells unwittingly contaminated with
mycoplasma microorganisms. In addition, as cell populations are passaged for extended periods, elusive
epigenetic changes may arise that can go unnoticed and alter experimental results. Finally, in research
involving isolating a specific cell type from primary tissue, small subpopulations of unwanted cells may
overgrow and replace the cells of interest. The failure of researchers to detect these problems and
changes can lead to erroneous experimental results, wasting valuable time and research funds.
The proposed SBIR research aims to develop an innovative instrument to assist researchers in detecting
these subtle yet critical issues before they jeopardize research efforts. The Cell Assurance Monitor
(CAM) is based on a technology where cells are cultured upon electrodes carrying weak AC signals. By
monitoring the complex impedance of these electrode substrates at multiple AC frequencies, several
parameters related to cell morphology and behavior can be discerned.
In past studies, impedance measurements did not fully leverage their multifaceted nature. However, in
feasibility studies with Cornell University, multivariate statistical analysis has been used to show the
ability of

The company sits in the national institute of general medical sciences segment, where it competes on its core product or service.

The business is associated with TROY, NY.

The company is listed at the SBIR/STTR stage of development.

Its team size is recorded as 11-50 employees.

Total disclosed funding stands at about $901K.

Website: biophysics.com