Applications of DNA Foundation Models

Show HN: Applications of DNA Foundation Models

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DNA models have been chalked up to be pretty useless but I think that's not true. I sketch out reasons why I think they are useful. Feedback and comments welcome. High-level takeaways:1) a Prime Intellect like RL environment for biology can unlock a lot of value for DNA models, but first needs to be built 2) like most deep learning models, data is king. Curating high quality low sample size task specific data to fine tune a general dna model is the clearest path to realizing value here 3) Specific applications I find interesting are CAR T promoter design, AAV gene therapy regulatory element design, reassigning variants of uncertain significance, bridging the variant to function gap, and bios

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Website: www.aditharun.com/p/dna-foundation-models